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JPS016NC

Cat. No. 8084 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative control for JPS036 (Cat. No. 8085).
Chemical Name: (2S,4S)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JPS016NC

JPS016NC is the negative control for JPS036 (Cat. No. 8085).

Licensing Information

Sold under license from the University of Leicester

Technical Data for JPS016NC

M. Wt 898.13
Formula C48H63N7O8S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 3031358-94-5
InChI Key BOXZMOCGSKLDAH-REIIXUMVSA-N
Smiles NC(C=CC=C1)=C1NC(C(C=C2)=CC=C2NC(COCCCCCCCCCOCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@@H](C3)O)C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JPS016NC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 89.81 100

Preparing Stock Solutions for JPS016NC

The following data is based on the product molecular weight 898.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.11 mL 5.57 mL 11.13 mL
5 mM 0.22 mL 1.11 mL 2.23 mL
10 mM 0.11 mL 0.56 mL 1.11 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for JPS016NC

References are publications that support the biological activity of the product.

Smalley et al (2022) Optimization of class I histone deacetylase PROTACs reveals that HDAC1/2 degradation is critical to induce apoptosis and cell arrest in cancer cells. J.Med.Chem. 65 5642 PMID: 35293758

If you know of a relevant reference for JPS016NC, please let us know.

View Related Products by Target

Keywords: JPS016NC, JPS016NC supplier, JPS016, negative, control, PROTAC, PROTACs, degraders, degrades, proteolysis-targeting, chimera, apoptosis, cancer, Negative, Controls, Class, I, HDACs, 8084, Tocris Bioscience

Citations for JPS016NC

Citations are publications that use Tocris products.

Currently there are no citations for JPS016NC. Do you know of a great paper that uses JPS016NC from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia