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JQ dS-4

Cat. No. 8152 Submit a Review Datasheet / COA / SDS
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Description: BRG1/SMARCA4 Degrader (PROTAC®)
Chemical Name: 3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JQ dS-4

JQ dS-4 is a Brahma-related gene 1 (BRG1)/BRM/SMARCA4 Degrader (PROTAC®; IC50 range = 9 - 390 nM in glioma models and cell lines). Comprises a BRG1 inhibitor joined by a linker to a cereblon (CRBN) E3 ligase ligand. Completely degrades BRG1 after 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells and reduces viability of a variety of cancer cell lines including H3K27M glioma, prostate, thyroid and salivary gland.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for JQ dS-4

M. Wt 719.16
Formula C37H31ClN8O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2688882-69-9
PubChem ID 156829976
InChI Key IIYWQMYQROKRFZ-UHFFFAOYSA-N
Smiles O=C(NC1=CC(C#CC2=CC=CC(C(NCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=C2)=NC=C1)NC6=CC(Cl)=NC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JQ dS-4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 71.92 100

Preparing Stock Solutions for JQ dS-4

The following data is based on the product molecular weight 719.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.95 mL 13.91 mL
5 mM 0.28 mL 1.39 mL 2.78 mL
10 mM 0.14 mL 0.7 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Molarity Calculator

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References for JQ dS-4

References are publications that support the biological activity of the product.

Panditharatna et al (2022) BAF complex maintains glioma stem cells in pediatric H3K27M glioma. Cancer Discov. 12 2880 PMID: 36305736

If you know of a relevant reference for JQ dS-4, please let us know.

View Related Products by Target

Keywords: JQ dS-4, JQ dS-4 supplier, JQDS4, degrader, degraders, degrades, BRG1, BRM, SMARCA4, CRBN, E3, ligase, ubiquitin, cancer, glioma, protac, protacs, proteolysis, targeting, chimera, chimeras, Bromodomain, (BRD), Degraders, Bromodomains, 8152, Tocris Bioscience

Citations for JQ dS-4

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia