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JTV 519 fumarate

Cat. No. 4564 2 Citations Submit a Review Datasheet / COA / SDS
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Description: Ryanodine receptor (RyR) inhibitor
Alternative Names: K 201
Chemical Name: 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JTV 519 fumarate

JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Technical Data for JTV 519 fumarate

M. Wt 540.67
Formula C25H32N2O2S.C4H4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1883549-36-7
PubChem ID 91826075
InChI Key ISLOBKLDZGDFTB-WLHGVMLRSA-N
Smiles O=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JTV 519 fumarate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.07 100

Preparing Stock Solutions for JTV 519 fumarate

The following data is based on the product molecular weight 540.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.5 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets for JTV 519 fumarate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for JTV 519 fumarate

References are publications that support the biological activity of the product.

Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID: 17313373

Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID: 17994112

Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID: 21989257

If you know of a relevant reference for JTV 519 fumarate, please let us know.

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Keywords: JTV 519 fumarate, JTV 519 fumarate supplier, JTV519, fumarate, K201, ryanodine, receptors, inhibitors, inhibits, ryr1, ryr2, antiarrythmic, cardioprotective, K, 201, Ryanodine, Receptors, 4564, Tocris Bioscience

2 Citations for JTV 519 fumarate

Citations are publications that use Tocris products. Selected citations for JTV 519 fumarate include:

Andreia S et al (2023) Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells. Cell Rep Methods 3 100456 PMID: 37159667

Chih-Cheng et al (2021) ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10 PMID: 34569932

Do you know of a great paper that uses JTV 519 fumarate from Tocris? Please let us know.

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