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JW 480

Cat. No. 4327 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JW 480

JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data for JW 480

M. Wt 333.42
Formula C22H23NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1354359-53-7
PubChem ID 57330099
InChI Key PCNJGBMWAZRVEA-UHFFFAOYSA-N
Smiles CC(C)C1=CC=CC=C1OC(NCCC2=CC=C(C=CC=C3)C3=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JW 480

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.34 100
ethanol 33.34 100

Preparing Stock Solutions for JW 480

The following data is based on the product molecular weight 333.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for JW 480

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for JW 480

References are publications that support the biological activity of the product.

Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476 PMID: 21513884

If you know of a relevant reference for JW 480, please let us know.

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Citations for JW 480

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