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Submit ReviewJZL 195
Description: Dual FAAH and MAGL inhibitor
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
Purity: ≥98% (HPLC)
Biological Activity for JZL 195
JZL 195 is a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.
Compound Libraries for JZL 195
JZL 195 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for JZL 195
| M. Wt | 433.46 |
| Formula | C24H23N3O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1210004-12-8 |
| PubChem ID | 46232606 |
| InChI Key | QNYRAEKLMNDRFY-UHFFFAOYSA-N |
| Smiles | O=C(OC4=CC=C([N+]([O-])=O)C=C4)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JZL 195
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.67 | 50 |
Preparing Stock Solutions for JZL 195
The following data is based on the product molecular weight 433.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.61 mL | 23.07 mL | 46.14 mL |
| 2.5 mM | 0.92 mL | 4.61 mL | 9.23 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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Product Datasheets for JZL 195
References for JZL 195
References are publications that support the biological activity of the product.
Wise et al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369 PMID: 22860205
Long et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270 PMID: 19918051
Wiskerke et al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407 PMID: 22860210
If you know of a relevant reference for JZL 195, please let us know.
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Keywords: JZL 195, JZL 195 supplier, JZL195, FAAH, fatty, acid, amide, hydrolase, monoacylglycerol, lipase, MAGL, inhibitors, inhibits, dual, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4715, Tocris Bioscience
Citations for JZL 195
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Currently there are no citations for JZL 195. Do you know of a great paper that uses JZL 195 from Tocris? Please let us know.
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