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JZP 430

Cat. No. 5844 Submit a Review Datasheet / COA / SDS
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Description: Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name: 4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JZP 430

JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Compound Libraries for JZP 430

JZP 430 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JZP 430

M. Wt 354.47
Formula C16H26N4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1672691-74-5
PubChem ID 121513897
InChI Key WKSHMJCYWFOADB-UHFFFAOYSA-N
Smiles O=C(N(C)C1CCCCCCC1)OC2=NSN=C2N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JZP 430

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.72 50
ethanol 7.09 20

Preparing Stock Solutions for JZP 430

The following data is based on the product molecular weight 354.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.21 mL 56.42 mL
2.5 mM 1.13 mL 5.64 mL 11.28 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

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References for JZP 430

References are publications that support the biological activity of the product.

Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253 PMID: 25504894

If you know of a relevant reference for JZP 430, please let us know.

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Citations for JZP 430

Citations are publications that use Tocris products.

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