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Submit ReviewKartogenin
Description: Potently induces chondrogenesis in MSCs
Chemical Name: 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for Kartogenin
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
Compound Libraries for Kartogenin
Kartogenin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Kartogenin
| M. Wt | 317.34 |
| Formula | C20H15NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 4727-31-5 |
| PubChem ID | 2826191 |
| InChI Key | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC=C(C3=CC=CC=C3)C=C2)C1=CC=CC=C1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kartogenin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.73 | 100 | |
| ethanol | 15.87 | 50 |
Preparing Stock Solutions for Kartogenin
The following data is based on the product molecular weight 317.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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Product Datasheets for Kartogenin
References for Kartogenin
References are publications that support the biological activity of the product.
Johnson et al (2012) A stem cell-based approach to cartilage repair. Science 336 717 PMID: 22491093
If you know of a relevant reference for Kartogenin, please let us know.
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Citations for Kartogenin
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Reviews for Kartogenin
Average Rating: 5 (Based on 1 Review.)
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Chondrogenic differentiation of human bone marrow stromal cells.
By
Nicola Foster on 08/28/2020
Assay Type: In Vitro
Species: Human
Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.
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