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KJ Pyr 9

Cat. No. 5306 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: High affinity Myc inhibitor
Chemical Name: 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KJ Pyr 9

KJ Pyr 9 is a high affinity Myc inhibitor (Kd = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.

Technical Data for KJ Pyr 9

M. Wt 385.37
Formula C22H15N3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 581073-80-5
PubChem ID 85855478
InChI Key GTTDVYCKFQYVNN-UHFFFAOYSA-N
Smiles O=C(N)C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KJ Pyr 9

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.54 100

Preparing Stock Solutions for KJ Pyr 9

The following data is based on the product molecular weight 385.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.97 mL 25.95 mL
5 mM 0.52 mL 2.59 mL 5.19 mL
10 mM 0.26 mL 1.3 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for KJ Pyr 9

References are publications that support the biological activity of the product.

Hart et al (2014) Inhibitor of MYC identified in a Kröhnke pyridine library. Proc.Natl.Acad.Sci.U.S.A. 111 12556 PMID: 25114221

If you know of a relevant reference for KJ Pyr 9, please let us know.

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Keywords: KJ Pyr 9, KJ Pyr 9 supplier, KJPyr9, high, affinity, myc, inhibitors, inhibits, Myc-max, brain, penetrant, Myc, MYC, 5306, Tocris Bioscience

2 Citations for KJ Pyr 9

Citations are publications that use Tocris products. Selected citations for KJ Pyr 9 include:

Chau et al (2018) Downregulation of ribosome biogenesis during early forebrain development. Elife. e36998 PMID: 29745900

Ana et al (2020) Acute liver failure is regulated by MYC- and microbiome-dependent programs. Nat Med 26 1899-1911 PMID: 33106666

Do you know of a great paper that uses KJ Pyr 9 from Tocris? Please let us know.

Reviews for KJ Pyr 9

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for KJ Pyr 9

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.