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Submit ReviewKLD 12
Description: Self-assembling peptide; forms hydrogel to support cell growth
Biological Activity for KLD 12
KLD 12 is a self-assembling peptide that forms a hydrogel matrix to support growth of cells in the presence of an ionic solution. Enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs).
Technical Data for KLD 12
| M. Wt | 1467.81 |
| Formula | C68H122N16O19 |
| Sequence |
KLDLKLDLKLDL (Modifications: Lys-1 = N-terminal Ac, Leu-12 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 800379-47-9 |
| InChI Key | JXVKXIMEQMJEAG-PEWBXTNBSA-N |
| Smiles | NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)NC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for KLD 12
References for KLD 12
References are publications that support the biological activity of the product.
Kisiday et al (2002) Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc.Natl.Acad.Sci.U.S.A. 99 9996 PMID: 12119393
Tripathi et al (2015) Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 56 92 PMID: 25934283
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Citations for KLD 12
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Currently there are no citations for KLD 12.
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Literature in this Area
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Stem Cell Research Product Guide
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.