Home / Pharmacology / Enzymes / Hydrolases / Monoacylglycerol Lipase / Monoacylglycerol Lipase Inhibitors / KT 182

KT 182

Cat. No. 6738 Submit a Review Datasheet / COA / SDS
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Description: Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name: [4-[3'-(Hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KT 182

KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.

Technical Data for KT 182

M. Wt 438.53
Formula C27H26N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1402612-62-7
PubChem ID 53364491
InChI Key GICNKPZHUCVFNM-UHFFFAOYSA-N
Smiles OCC1=CC=CC(C2=CC=C(C3=CN(C(N4CCCCC4C5=CC=CC=C5)=O)N=N3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KT 182

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.85 100

Preparing Stock Solutions for KT 182

The following data is based on the product molecular weight 438.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for KT 182

References are publications that support the biological activity of the product.

Hsu et al (2013) Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) J.Med.Chem. 56 8270 PMID: 24152295

If you know of a relevant reference for KT 182, please let us know.

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Keywords: KT 182, KT 182 supplier, KT182, potent, selective, irreversible, alpha/beta-hydrolase, α/β, alfa, domains, 6, ABHD6, inhibitors, inhibits, MAGL, 6738, Tocris Bioscience

Citations for KT 182

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