Home / Pharmacology / Enzymes / Hydrolases / Other Hydrolases / Other Hydrolase Inhibitors / KT 182

KT 182

Cat. No. 6738 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name: [4-[3'-(Hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KT 182

KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.

Technical Data for KT 182

M. Wt 438.53
Formula C27H26N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1402612-62-7
PubChem ID 53364491
InChI Key GICNKPZHUCVFNM-UHFFFAOYSA-N
Smiles OCC1=CC=CC(C2=CC=C(C3=CN(C(N4CCCCC4C5=CC=CC=C5)=O)N=N3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KT 182

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.85 100

Preparing Stock Solutions for KT 182

The following data is based on the product molecular weight 438.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for KT 182

References are publications that support the biological activity of the product.

Hsu et al (2013) Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) J.Med.Chem. 56 8270 PMID: 24152295

If you know of a relevant reference for KT 182, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Hydrolase Inhibitors

Keywords: KT 182, KT 182 supplier, KT182, potent, selective, irreversible, alpha/beta-hydrolase, α/β, alfa, domains, 6, ABHD6, inhibitors, inhibits, Other, Hydrolases, 6738, Tocris Bioscience

Citations for KT 182

Citations are publications that use Tocris products.

Currently there are no citations for KT 182. Do you know of a great paper that uses KT 182 from Tocris? Please let us know.

Reviews for KT 182

There are currently no reviews for this product. Be the first to review KT 182 and earn rewards!

Have you used KT 182?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review