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Submit ReviewL-701,252
Description: NMDA antagonist; acts at glycine site
Chemical Name: 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone
Purity: ≥99% (HPLC)
Biological Activity for L-701,252
L-701,252 is a an antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for L-701,252
| M. Wt | 263.68 |
| Formula | C13H10ClNO3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 151057-13-5 |
| PubChem ID | 54687453 |
| InChI Key | MXEFWCFPCLDOOG-UHFFFAOYSA-N |
| Smiles | OC1=C(C(=O)C2CC2)C(=O)NC2=C1C=CC(Cl)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-701,252
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50 |
Preparing Stock Solutions for L-701,252
The following data is based on the product molecular weight 263.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.58 mL | 37.92 mL | 75.85 mL |
| 2.5 mM | 1.52 mL | 7.58 mL | 15.17 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.58 mL |
| 25 mM | 0.15 mL | 0.76 mL | 1.52 mL |
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Product Datasheets for L-701,252
References for L-701,252
References are publications that support the biological activity of the product.
Rowley et al (1993) 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 36 3386 PMID: 8230129
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
If you know of a relevant reference for L-701,252, please let us know.
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Keywords: L-701,252, L-701,252 supplier, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, anticonvulsant, L701252, merck, 0705, Tocris Bioscience
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