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Submit ReviewL-701,324
Description: NMDA antagonist; acts at glycine site
Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Purity: ≥99% (HPLC)
Biological Activity for L-701,324
L-701,324 is a an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for L-701,324
| M. Wt | 363.8 |
| Formula | C21H14ClNO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 142326-59-8 |
| PubChem ID | 54682505 |
| InChI Key | FLVRDMUHUXVRET-UHFFFAOYSA-N |
| Smiles | OC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-701,324
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions for L-701,324
The following data is based on the product molecular weight 363.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.49 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets for L-701,324
References for L-701,324
References are publications that support the biological activity of the product.
Bristow et al (1996) The atypical neuroleptic profile of the glycine/N-MthD.-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 277 578 PMID: 8627534
Bristow et al (1996) Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex. J.Pharmacol.Exp.Ther. 279 492 PMID: 8930150
Kulagowski et al (1994) 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 37 1402 PMID: 8182696
Obrenovitch and Zilkha (1996) Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-MthD.-aspartate receptor complex. Br.J.Pharmacol. 117 931 PMID: 8851513
If you know of a relevant reference for L-701,324, please let us know.
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Keywords: L-701,324, L-701,324 supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, L701324, 0907, Tocris Bioscience
1 Citation for L-701,324
Citations are publications that use Tocris products. Selected citations for L-701,324 include:
Bäckström and Hyytiä (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 778 PMID: 16123768
Do you know of a great paper that uses L-701,324 from Tocris? Please let us know.
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