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Submit ReviewL-741,741 hydrochloride
Description: Potent, selective D4 antagonist
Chemical Name: 3-(4-Chlorophenyl)-4-methyl-5-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for L-741,741 hydrochloride
A potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 480 and 2.5 nM at cloned human D2, D3 and D4 receptors respectively.
Licensing Information
Sold the permission of Merck Sharpe and Dohme Ltd.
Technical Data for L-741,741 hydrochloride
| M. Wt | 417.38 |
| Formula | C23H25ClN2O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| Smiles | ClC4=CC=C(C=C4)C1=NOC(C(CC3)CCN3CCC2=CC=CC=C2)=C1C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-741,741 hydrochloride
Certificate of Analysis is currently unavailable on-line.
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References for L-741,741 hydrochloride
References are publications that support the biological activity of the product.
Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D4 receptors. J.Med.Chem 39 1943 PMID: 8642551
Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D4 receptor. J.Med.Chem. 40 2374 PMID: 9240352
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.