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Submit ReviewL-AP6
Description: Selective agonist of the 'quis' effect
Chemical Name: L-(+)-2-Amino-6-phosphonohexanoic acid
Biological Activity for L-AP6
L-AP6 is a selective agonist for 'quis'-sensitized site.
Technical Data for L-AP6
| M. Wt | 211.15 |
| Formula | C6H14NO5P |
| Storage | Store at RT |
| CAS Number | 78944-89-5 |
| PubChem ID | 3062646 |
| InChI Key | QIOXWRQXHFVNLV-YFKPBYRVSA-N |
| Smiles | [H][C@@](CCCCP(O)(O)=O)(N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-AP6
References for L-AP6
References are publications that support the biological activity of the product.
Johansen et al (1995) Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats. Mol.Pharmacol. 48 140 PMID: 7623768
Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634
Venkatraman et al (1994) Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus. J.Med.Chem. 37 3939 PMID: 7966155
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Keywords: L-AP6, L-AP6 supplier, Selective, agonists, quis, effect, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Miscellaneous, 0341, Tocris Bioscience
Citations for L-AP6
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.