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Submit ReviewL-BMAA hydrochloride
Description: Neurotoxic amino acid
Chemical Name: 3-(Methylamino)-L-alanine hydrochloride
Biological Activity for L-BMAA hydrochloride
L-BMAA hydrochloride is a neurotoxic glutamate agonist originally isolated from Cycas circinalis. Implicated in the pathogenesis of amyotrophic lateral sclerosis-Parkinsonism-dementia complex of Guam (Guam ALS-PD).
Technical Data for L-BMAA hydrochloride
| M. Wt | 154.6 |
| Formula | C4H10N2O2.HCl |
| Storage | Store at -20°C |
| CAS Number | 16012-55-8 |
| PubChem ID | 51358333 |
| InChI Key | VDXYGASOGLSIDM-DFWYDOINSA-N |
| Smiles | N[C@@H](CNC)C(O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-BMAA hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.28 | 60 |
Preparing Stock Solutions for L-BMAA hydrochloride
The following data is based on the product molecular weight 154.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.6 mM | 10.78 mL | 53.9 mL | 107.81 mL |
| 3 mM | 2.16 mL | 10.78 mL | 21.56 mL |
| 6 mM | 1.08 mL | 5.39 mL | 10.78 mL |
| 30 mM | 0.22 mL | 1.08 mL | 2.16 mL |
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Product Datasheets for L-BMAA hydrochloride
References for L-BMAA hydrochloride
References are publications that support the biological activity of the product.
Weiss et al (1989) Neurotoxicity of β-N-methylamino-L-alanine (BMAA) and β-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons. Brain Res. 497 64 PMID: 2551452
Vega et al (1968) The preparation of L- and D-α-amino-β<-methylaminopropionic acids and the identification of the compound isolated from Cycas circinalis as the L-isomer. Phytochemistry 7 1885
If you know of a relevant reference for L-BMAA hydrochloride, please let us know.
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Keywords: L-BMAA hydrochloride, L-BMAA hydrochloride supplier, Neurotoxic, amino, acid, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Miscellaneous, 2538, Tocris Bioscience
Citations for L-BMAA hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.