Home / Pharmacology / Enzymes / Synthases/Synthetases / Other Synthases/Synthetases / Other Synthase/Synthetase Inhibitors / L-Buthionine sulfoximine

L-Buthionine sulfoximine

Cat. No. 6954 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
Chemical Name: (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for L-Buthionine sulfoximine

L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; depletes glutathione levels by inhibiting synthesis. Induces ferroptosis in vitro.

Technical Data for L-Buthionine sulfoximine

M. Wt 222.3
Formula C8H18N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83730-53-4
PubChem ID 119565
InChI Key KJQFBVYMGADDTQ-CVSPRKDYSA-N
Smiles CCCC[S](=N)(=O)CC[C@H](N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-Buthionine sulfoximine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.23 100
DMSO 22.23 100

Preparing Stock Solutions for L-Buthionine sulfoximine

The following data is based on the product molecular weight 222.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.49 mL 44.98 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for L-Buthionine sulfoximine

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for L-Buthionine sulfoximine

References are publications that support the biological activity of the product.

Griffith & Meister (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J.Biol.Chem. 254 7558 PMID: 38242

Griffith et al (1982) Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J.Biol.Chem. 257 13704 PMID: 6128339

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385

If you know of a relevant reference for L-Buthionine sulfoximine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: L-Buthionine sulfoximine, L-Buthionine sulfoximine supplier, Buthionine, sulfoximine, BSO, L-BSO, gamma, glutamylcysteine, synthetase, inhibitors, inhibits, induces, ferroptosis, activiators, activates, g-GCS, glutamate, cysteine, ligase, GSL, Other, Synthases/Synthetases, Ferroptosis, 6954, Tocris Bioscience

1 Citation for L-Buthionine sulfoximine

Citations are publications that use Tocris products. Selected citations for L-Buthionine sulfoximine include:

Gregory H et al (2021) Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep 37 110037 PMID: 34818536

Do you know of a great paper that uses L-Buthionine sulfoximine from Tocris? Please let us know.

Reviews for L-Buthionine sulfoximine

There are currently no reviews for this product. Be the first to review L-Buthionine sulfoximine and earn rewards!

Have you used L-Buthionine sulfoximine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review