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Submit ReviewL-NAME hydrochloride
Description: Non-selective NOS inhibitor
Chemical Name: NG-Nitro-L-arginine methyl ester hydrochloride
Biological Activity for L-NAME hydrochloride
L-NAME hydrochloride is a NO synthase inhibitor.
Compound Libraries for L-NAME hydrochloride
L-NAME hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for L-NAME hydrochloride
| M. Wt | 269.69 |
| Formula | C7H15N5O4.HCl |
| Storage | Store at RT |
| CAS Number | 51298-62-5 |
| PubChem ID | 135193 |
| InChI Key | QBNXAGZYLSRPJK-JEDNCBNOSA-N |
| Smiles | N=C(NCCC[C@H](N)C(OC)=O)N[N+]([O-])=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-NAME hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.97 | 100 | |
| DMSO | 26.97 | 100 |
Preparing Stock Solutions for L-NAME hydrochloride
The following data is based on the product molecular weight 269.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.54 mL | 37.08 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.42 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for L-NAME hydrochloride
References for L-NAME hydrochloride
References are publications that support the biological activity of the product.
Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
Pfeiffer et al (1996) Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br.J.Pharmacol. 118 1433 PMID: 8832069
If you know of a relevant reference for L-NAME hydrochloride, please let us know.
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Keywords: L-NAME hydrochloride, L-NAME hydrochloride supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthase, NO, Synthases, iNOS, eNOS, nNOS, Non-selective, 0665, Tocris Bioscience
20 Citations for L-NAME hydrochloride
Citations are publications that use Tocris products. Selected citations for L-NAME hydrochloride include:
Gallo and Iadecola (2011) Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci 31 6947 PMID: 21562256
Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924
Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037
Bice et al (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res 101 220 PMID: 24259501
Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256
Orru et al (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology 67 476 PMID: 23261866
Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451
Gibson et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746 PMID: 18341994
Cameron (2017) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu. Sci Rep 7 10578 PMID: 28874749
Lou et al (2009) Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation. Exp Biol Med (Maywood) 234 1374 PMID: 19657070
Pearson et al (2009) Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function. Am J Physiol Endocrinol Metab 297 E647 PMID: 19549792
Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. Proc Natl Acad Sci U S A 35 5664 PMID: 25855180
Townsend and Emala (2013) Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Am J Physiol Lung Cell Mol Physiol 305 L396 PMID: 23873842
Vaish and Singh (2013) Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus. Br J Cancer 2013 312146 PMID: 23690783
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609
Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079
Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Microbiol 97 11593 PMID: 11016958
Chen et al (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa J Virol 76 9407 PMID: 12186923
Safo and Regehr (2005) Endocannabinoids control the induction of cerebellar LTD. Neuron 48 647 PMID: 16301180
Do you know of a great paper that uses L-NAME hydrochloride from Tocris? Please let us know.
Reviews for L-NAME hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Effective nitric oxide synthase blocker.
By
Karthik krishnamurthy on 10/26/2018
Species: Rat
Cell Line/Tissue: astrocytes
Measured time lapse production of nitric oxide in astrocytes stimulated with 30 μM UTP with and without pretreatment with 100 μM L-NAME.
