Home / Pharmacology / Enzymes / Hydrolases / Lysosomal Acid Lipase / Lysosomal Acid Lipase Inhibitors / Lalistat 1

Lalistat 1

Cat. No. 6098 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective LAL inhibitor
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Lalistat 1

Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.

Compound Libraries for Lalistat 1

Lalistat 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Lalistat 1

M. Wt 298.36
Formula C12H18N4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 501104-16-1
PubChem ID 648404
InChI Key GKOPFXFKPASEFI-UHFFFAOYSA-N
Smiles O=C(OC1=NSN=C1N2CCCCC2)N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lalistat 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.84 100
ethanol 29.84 100

Preparing Stock Solutions for Lalistat 1

The following data is based on the product molecular weight 298.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Lalistat 1

References are publications that support the biological activity of the product.

Rosenbaum et al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313

Ouimet et al (2011) Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 13 655 PMID: 21641547

Rosenbaum et al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099

If you know of a relevant reference for Lalistat 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Lysosomal Acid Lipase Inhibitors

Keywords: Lalistat 1, Lalistat 1 supplier, potent, selective, LAL, inhibitors, inhibits, lysosomal, acid, lipase, Neimann-Pick, type, c, NPC, storage, cholesterol, accumulation, Lalistat1, Lysosomal, Acid, Lipase, (LAL), 6098, Tocris Bioscience

3 Citations for Lalistat 1

Citations are publications that use Tocris products. Selected citations for Lalistat 1 include:

Wu et al (2019) Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes. Hepatol Commun 3 406 PMID: 30859152

Shaun G et al (2019) Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. J Cell Biol 218 3320-3335 PMID: 31391210

Mariam et al (2021) Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Autophagy 17 690-705 PMID: 32070194

Do you know of a great paper that uses Lalistat 1 from Tocris? Please let us know.

Reviews for Lalistat 1

There are currently no reviews for this product. Be the first to review Lalistat 1 and earn rewards!

Have you used Lalistat 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review