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Submit ReviewLamotrigine isethionate
Description: Inhibits glutamate release. Water-soluble salt of lamotrigine (Cat. No. 1611)
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate
Purity: ≥99% (HPLC)
Biological Activity for Lamotrigine isethionate
Lamotrigine isethionate is a water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for Lamotrigine isethionate
| M. Wt | 382.22 |
| Formula | C9H7Cl2N5.C2H6O4S |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 113170-86-8 |
| PubChem ID | 45039646 |
| InChI Key | CJIDZLNMKONKAD-UHFFFAOYSA-N |
| Smiles | OCCS(O)(=O)=O.NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Lamotrigine isethionate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 38.22 | 100 with gentle warming |
Preparing Stock Solutions for Lamotrigine isethionate
The following data is based on the product molecular weight 382.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.08 mL | 26.16 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for Lamotrigine isethionate
References for Lamotrigine isethionate
References are publications that support the biological activity of the product.
Leach et al (1991) Neurochemical and behavioral aspects of lamotr. Epilepsia 32 S4 PMID: 1685439
Smith and Meldrum (1995) Cardioprotective effect of lamotr. after focal ischemia in rats. Stroke 26 117 PMID: 7839380
Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596
Grunze et al (1998) Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 38 131 PMID: 9778600
If you know of a relevant reference for Lamotrigine isethionate, please let us know.
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Keywords: Lamotrigine isethionate, Lamotrigine isethionate supplier, inhibitors, inhibits, glutamate, release, Receptors, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, 2289, Tocris Bioscience
1 Citation for Lamotrigine isethionate
Citations are publications that use Tocris products. Selected citations for Lamotrigine isethionate include:
Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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