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LDN 193188

Cat. No. 5631 Submit a Review Datasheet / COA / SDS
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Description: Inhibitor of phosphatidylcholine transfer protein (PC-TP)
Chemical Name: 2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
Purity: ≥99% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for LDN 193188

LDN 193188 is an inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.

Technical Data for LDN 193188

M. Wt 494.35
Formula C20H17Cl2N5O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1267610-30-9
PubChem ID 66958626
InChI Key COTBDKMEUUNJTI-UHFFFAOYSA-N
Smiles O=C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=O)C3=C(Cl)C=C(Cl)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LDN 193188

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.44 100

Preparing Stock Solutions for LDN 193188

The following data is based on the product molecular weight 494.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.23 mL
5 mM 0.4 mL 2.02 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for LDN 193188

References are publications that support the biological activity of the product.

Shishova et al (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54 664 PMID: 21538437

Wagle et al (2008) Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 383 85 PMID: 18762160

If you know of a relevant reference for LDN 193188, please let us know.

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Citations for LDN 193188

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