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Submit ReviewLDN 193189
Description: LDN 193189 synthesized to cGMP guidelines
Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥99%
Biological Activity for LDN 193189
LDN 193189 synthesized to cGMP guidelines. Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.
Research use only LDN 193189 also available.
Licensing Information
Sold for research purposes only under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484. A license may be required for use in stem cell-based therapies. Please contact Technical Support for further details: techsupport@bio-techne.com.
Current Good Manufacturing Practice (cGMP) is a harmonized set of guidelines that when implemented will ensure safe, reliable, consistent and quality-assured products. The Tocris range of cGMP small molecules is manufactured following relevant sections of ICH Q7 guidelines. Our highly skilled team has full control over the cGMP process, meaning we can ensure: a quality-assured manufacturing system, batch-to-batch consistency, consistent supply, traceability from starting material to final product, and animal-free production. Find out more about the Tocris range of cGMP compounds.
Technical Data for LDN 193189
| M. Wt | 479.4 |
| Formula | C25H22N6.2HCl |
| Storage | Store at -20°C(±5°C) |
| Purity | ≥99% |
| CAS Number | 1435934-00-1 |
| InChI Key | CMQXLLAILGGLRV-UHFFFAOYSA-N |
| Smiles | N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
This product is intended for research use or further manufacturing only.
Product Datasheets for LDN 193189
Certificate of Analysis is currently unavailable on-line.
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References for LDN 193189
References are publications that support the biological activity of the product.
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Citations for LDN 193189
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Protocols for LDN 193189
The following protocols feature additional information for the use of LDN 193189 (Cat. No. TB6053-GMP).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.