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Submit ReviewLDN 212320
Description: Increases EAAT2 expression; neuroprotective
Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
Purity: ≥98% (HPLC)
Biological Activity for LDN 212320
LDN 212320 is a increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
Technical Data for LDN 212320
| M. Wt | 293.39 |
| Formula | C17H15N3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 894002-50-7 |
| PubChem ID | 7207425 |
| InChI Key | DUUQLWDHNYFUPP-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LDN 212320
References for LDN 212320
References are publications that support the biological activity of the product.
Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689 PMID: 22924507
Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774 PMID: 21875806
Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99
Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103
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Keywords: LDN 212320, LDN 212320 supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Glutamate, 5082, Tocris Bioscience
1 Citation for LDN 212320
Citations are publications that use Tocris products. Selected citations for LDN 212320 include:
Matthew P et al (2021) The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics. Front Cell Neurosci 15 661412 PMID: 33841104
Reviews for LDN 212320
Average Rating: 4 (Based on 1 Review.)
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Using LDN 212320 to increase GLT-1.
By
Crystal Wilkie on 01/12/2018
Species: Mouse
We used it to increase GLT-1 in mice brains. So far it has significantly increased GLT-1 after one injection.
It's hard to dissolve so we dissolved it in 100ul of DMSO first before adding the vehicle.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.