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Letrozole

Cat. No. 4382 4 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, reversible non-steroidal aromatase inhibitor
Alternative Names: CGS 20267
Chemical Name: 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Letrozole

Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.

Compound Libraries for Letrozole

Letrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Letrozole

M. Wt 285.3
Formula C17H11N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 112809-51-5
PubChem ID 3902
InChI Key HPJKCIUCZWXJDR-UHFFFAOYSA-N
Smiles N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Letrozole

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.53 100

Preparing Stock Solutions for Letrozole

The following data is based on the product molecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.05 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Letrozole

References are publications that support the biological activity of the product.

Mitropoulou et al (2003) Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 104 155 PMID: 12569569

Bhatnagar et al (1990) Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 37 1021 PMID: 2149502

Bhatnagar (2007) The discovery and mechanism of action of letr. Breast Cancer Res.Treat. 105 7 PMID: 17912633

If you know of a relevant reference for Letrozole, please let us know.

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Keywords: Letrozole, Letrozole supplier, CGS20267, non-steroidal, aromatase, CYP19, inhibitors, inhibits, potent, reversible, antitumor, antitumour, CGS, 20267, Cytochrome, P450, Estrogen, and, Related, Receptors, 4382, Tocris Bioscience

4 Citations for Letrozole

Citations are publications that use Tocris products. Selected citations for Letrozole include:

Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768

Ruiz-Palmero et al (2016) OOE synthesized by female neurons generates sex differences in neuritogenesis. Scientific Reports 6 31891 PMID: 27553191

Xin-Ming et al (2023) Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats. Int J Mol Sci 24 PMID: 36674721

Ali et al (2017) Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer 17 803 PMID: 29187162

Do you know of a great paper that uses Letrozole from Tocris? Please let us know.

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