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Submit Review[Leu5]-Enkephalin
Description: Endogenous opioid agonist peptide
Alternative Names: ICI 114740,Dynorphin-(1-5),YGGFL
Purity: ≥95% (HPLC)
Biological Activity for [Leu5]-Enkephalin
[Leu5]-Enkephalin is an endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.
Technical Data for [Leu5]-Enkephalin
| M. Wt | 555.63 |
| Formula | C28H37N5O7 |
| Sequence | YGGFL |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 58822-25-6 |
| PubChem ID | 461776 |
| InChI Key | URLZCHNOLZSCCA-VABKMULXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for [Leu5]-Enkephalin
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for [Leu5]-Enkephalin
References for [Leu5]-Enkephalin
References are publications that support the biological activity of the product.
DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432 PMID: 6296388
Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409 PMID: 705021
Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920
If you know of a relevant reference for [Leu5]-Enkephalin, please let us know.
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Keywords: [Leu5]-Enkephalin, [Leu5]-Enkephalin supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, ICI, 114740, Dynorphin-(1-5), YGGFL, Miscellaneous/Non-selective, Opioids, 1889, Tocris Bioscience
1 Citation for [Leu5]-Enkephalin
Citations are publications that use Tocris products. Selected citations for [Leu5]-Enkephalin include:
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
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