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Submit ReviewLG 101506
Description: Selective RXR modulator
Alternative Names: LG 1506
Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Purity: ≥98% (HPLC)
Biological Activity for LG 101506
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.
Technical Data for LG 101506
| M. Wt | 420.53 |
| Formula | C25H34F2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 331248-11-4 |
| PubChem ID | 9845057 |
| InChI Key | BHIBZAZKKARFIM-XRYBSMBUSA-N |
| Smiles | CC(C)(C)C1=CC(/C(C)=C\C=C\C(C)=C\C(O)=O)=C(OCC(F)F)C(C(C)(C)C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LG 101506
References for LG 101506
References are publications that support the biological activity of the product.
Michellys et al (2003) Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 46 2683 PMID: 12801232
Leibowitz et al (2006) Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 147 1044 PMID: 16269450
Pinaire et al (2007) Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 94156 PMID: 17497022
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Keywords: LG 101506, LG 101506 supplier, LG101506, retinoid, x, receptors, rxr, modulators, rxra, rxrb, rxrg, rxralpha, rxrbeta, rxrgamma, rxrα, rxrβ, rxrγ, LG1506, LG_1506, LG, 1506, Retinoid, X, Receptor, 3508, Tocris Bioscience
1 Citation for LG 101506
Citations are publications that use Tocris products. Selected citations for LG 101506 include:
Ronn et al (2015) Retinoic Acid regulates hematopoietic development from human pluripotent stem cells. Development 4 269 PMID: 25680478
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.