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Submit ReviewLIH 383 New
Description: Atypical chemokine receptor (ACKR3) agonist
Purity: ≥95% (HPLC)
Biological Activity for LIH 383
LIH 383 is a potent and highly selective atypical chemokine receptor (ACKR3/CXCR7) agonist. LIH 383 competes directly with CXCL12-AF647 and is more potent in inducing β-arrestin recruitment to ACKR3 (EC50 = 0.61 nM) than the full-length chemokine ligands CXCL12 or CXCL11 (EC50 values are 1.2 nM and 2.2 nM, respectively). In a rat ex vivo model, LIH 383 increases the availability and signaling of opioid peptides at classical receptors.
Licensing Information
Sold under patent license from Luxembourg Institute of Health.
Technical Data for LIH 383
| M. Wt | 997.23 |
| Formula | C45H72N16O8S |
| Sequence |
FGGFMRRK (Modification: Lys-8 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2866266-58-0 |
| InChI Key | HKVZPBVWPFDBBQ-LBBUGJAGSA-N |
| Smiles | O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LIH 383
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for LIH 383
References for LIH 383
References are publications that support the biological activity of the product.
Meyrath et al (2020) The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat.Commun. 11 3033 PMID: 32561830
Kleist et al (2022) Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. Science 377 222 PMID: 35857540
If you know of a relevant reference for LIH 383, please let us know.
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Keywords: LIH 383, LIH 383 supplier, LIH383, agonists, ACKR3, cxcr7, chemokines, atypical, chemokine, receptor, CXC, Receptors, potent, selective, opioid, peptides, Chemokine, 8095, Tocris Bioscience
Citations for LIH 383
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