Liproxstatin-1 hydrochloride

Cat. No. 6113 Submit a Review Datasheet / COA / SDS

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Description: Potent ferroptosis inhibitor

Chemical Name: N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (3)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC₅₀ = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Compound Libraries for Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Liproxstatin-1 hydrochloride

M. Wt	377.31
Formula	C₁₉H₂₁ClN₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250025-95-5
PubChem ID	134160236
InChI Key	HEHOHTKMIOBTKC-UHFFFAOYSA-N
Smiles	C1CNCCC12C(=NC3=CC=CC=C3N2)NCC4=CC(=CC=C4)Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Liproxstatin-1 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.73	100

Preparing Stock Solutions for Liproxstatin-1 hydrochloride

The following data is based on the product molecular weight 377.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Product Datasheets for Liproxstatin-1 hydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Liproxstatin-1 hydrochloride

References are publications that support the biological activity of the product.

Friedmann Angeli et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16 1180 PMID: 25402683

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Keywords: Liproxstatin-1 hydrochloride, Liproxstatin-1 hydrochloride supplier, 950455-15-9, ferroptosis, inhibitor, inhibits, potent, GPX4, Ferroptosis, 6113, Tocris Bioscience

Citations for Liproxstatin-1 hydrochloride

Citations are publications that use Tocris products.

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Reviews for Liproxstatin-1 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for Liproxstatin-1 hydrochloride

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.