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Description: Potent SMYD2 inhibitor
Chemical Name: 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for LLY 507
LLY 507 is a potent SMYD2 inhibitor (IC50 = 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LLY 507 probe summary on the SGC website.
External Portal Information for LLY 507
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LLY 507 is reviewed on the chemical probes website.
Technical Data for LLY 507
| M. Wt | 574.76 |
| Formula | C36H42N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1793053-37-8 |
| PubChem ID | 91623361 |
| InChI Key | PNYRDVBFYVDJJI-UHFFFAOYSA-N |
| Smiles | CC(C5=C4C=CC=C5)=CN4CCN(CC3)CCN3C1=C(C2=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C2)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LLY 507
References for LLY 507
References are publications that support the biological activity of the product.
Nguyen et al (2015) LLY-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase SMYD2. J.Biol.Chem. 290 13641 PMID: 25825497
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Keywords: LLY 507, LLY 507 supplier, LLY507, potent, selective, SMYD2, inhibitors, inhibits, lysine, methyltransferases, p53, Other, Lysine, Methyltransferases, 5365, Tocris Bioscience
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