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Description: Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
Chemical Name: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Purity: ≥98% (HPLC)
Biological Activity for LNT 1
LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.
Compound Libraries for LNT 1
LNT 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LNT 1
| M. Wt | 332.33 |
| Formula | C15H12N2O5S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 824983-91-7 |
| PubChem ID | 11652865 |
| InChI Key | MXQGCMQXTPTJJT-UHFFFAOYSA-N |
| Smiles | ON1C(N(C2=C(C1=O)SC=C2)CC3COC4=CC=CC=C4O3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LNT 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 50 |
Preparing Stock Solutions for LNT 1
The following data is based on the product molecular weight 332.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 2.5 mM | 1.2 mL | 6.02 mL | 12.04 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 25 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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Product Datasheets for LNT 1
References for LNT 1
References are publications that support the biological activity of the product.
Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID: 27526030
Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID: 28628639
If you know of a relevant reference for LNT 1, please let us know.
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1 Citation for LNT 1
Citations are publications that use Tocris products. Selected citations for LNT 1 include:
Mai et al (2021) NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. NAR Cancer 3 zcab044 PMID: 34806016
Do you know of a great paper that uses LNT 1 from Tocris? Please let us know.
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