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Submit ReviewLOE 908 hydrochloride
Description: Broad spectrum cation channel blocker; neuroprotective
Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for LOE 908 hydrochloride
LOE 908 hydrochloride is a broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
Technical Data for LOE 908 hydrochloride
| M. Wt | 749.29 |
| Formula | C41H48N2O9.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 143482-60-4 |
| PubChem ID | 56846451 |
| InChI Key | UDKSNBMNKLDHNK-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=C(CCN(CCC2=C(OC)C(OC)=C(OC)C=C2)C(=O)C(C2=CC=CC=C2)C2=NCCC3=CC(OC)=C(OC)C=C23)C(OC)=C1OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LOE 908 hydrochloride
References for LOE 908 hydrochloride
References are publications that support the biological activity of the product.
Christensen et al (2005) The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 96 316 PMID: 15755315
Krause et al (1998) LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 244 659 PMID: 9535721
Tatlisumak et al (2000) Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurol.Sci. 178 107 PMID: 11018702
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2 Citations for LOE 908 hydrochloride
Citations are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:
Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603 PMID: 23457590
Harper and Poole (2010) Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem 285 19865 PMID: 20388711
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