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Submit ReviewLorazepam
Description: Ligand at benzodiazepine site
Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one
Biological Activity for Lorazepam
Ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Technical Data for Lorazepam
| M. Wt | 321.16 |
| Formula | C15H10Cl2N2O2 |
| Storage | Store at RT |
| CAS Number | 846-49-1 |
| PubChem ID | 3958 |
| InChI Key | DIWRORZWFLOCLC-UHFFFAOYSA-N |
| Smiles | O=C2C(O)N=C(C3=CC=CC=C3Cl)C1=CC(Cl)=CC=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Lorazepam
References for Lorazepam
References are publications that support the biological activity of the product.
Bonavita et al (2002) Tolerance to the sedative effect of L.pam correlates with a diminution in cortical release and affinity for glutamate. Neuropharmacol. 42 619
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Keywords: Lorazepam, Lorazepam supplier, Acts, benzodiazepine, modulatory, site, GABAA, Receptors, 3087, Tocris Bioscience
Citations for Lorazepam
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Currently there are no citations for Lorazepam.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.