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Submit ReviewLP 20 hydrochloride
Description: Selective 5-HT7 ligand
Chemical Name: 1-(4'-Methoxy[1,1-biphenyl]-2-yl)piperazine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for LP 20 hydrochloride
Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).
Licensing Information
Sold under license from the University of Bari
Technical Data for LP 20 hydrochloride
| M. Wt | 304.81 |
| Formula | C17H20N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1386928-34-2 |
| PubChem ID | 22001617 |
| InChI Key | KXZUJPBDJNUNCN-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3C1=CC=CC=C1N2CCNCC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LP 20 hydrochloride
References for LP 20 hydrochloride
References are publications that support the biological activity of the product.
Lacivita et al (2012) Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J.Med.Chem. 55 6375 PMID: 22738316
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Citations for LP 20 hydrochloride
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Currently there are no citations for LP 20 hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.