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Submit ReviewLP 44
Description: High affinity 5-HT7 agonist
Chemical Name: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for LP 44
High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
Licensing Information
Sold under license from the University of Bari
Technical Data for LP 44
| M. Wt | 488.13 |
| Formula | C27H37N3OS.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 824958-12-5 |
| PubChem ID | 11225543 |
| InChI Key | DWGKCWWWKHCVDH-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCN3CCN(C4=C(SC)C=CC=C4)CC3)NC1CCCC2=C1C=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LP 44
References for LP 44
References are publications that support the biological activity of the product.
Leopoldo et al (2004) Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem. 47 6616 PMID: 15588097
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Keywords: LP 44, LP 44 supplier, High, affinity, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP44, 2534, Tocris Bioscience
2 Citations for LP 44
Citations are publications that use Tocris products. Selected citations for LP 44 include:
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Mol Med 3 e00103 PMID: 25692021
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.