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Submit ReviewLP 922056
Description: Notum inhibitor; activates Wnt signaling
Chemical Name: 2-[(6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio]acetic acid
Purity: ≥98% (HPLC)
Biological Activity for LP 922056
LP 922056 is a notum pectinacetylesterase inhibitor. LP 922056 activates wnt signaling in vitro (EC50 values are 21 nM in human and 55 nM in mouse cell-based assay). It increases cortical bone thickness in mouse model of bone growth. LP 922056 also inhibits growth of Apc-mutant cell lines and proliferation of intestinal adenomas in vivo.
Compound Libraries for LP 922056
LP 922056 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for LP 922056
| M. Wt | 300.78 |
| Formula | C11H9ClN2O2S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1365060-22-5 |
| PubChem ID | 56932967 |
| InChI Key | LJYRIWUQISYYHA-UHFFFAOYSA-N |
| Smiles | OC(CSC1=C2SC(Cl)=C(C2=NC=N1)C3CC3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LP 922056
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.08 | 100 |
Preparing Stock Solutions for LP 922056
The following data is based on the product molecular weight 300.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.62 mL | 33.25 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.65 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets for LP 922056
References for LP 922056
References are publications that support the biological activity of the product.
Tarver et al (2016) Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 26 1525 PMID: 26897593
Brommage et al (2019) NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 7 PMID: 30622831
Flanagan et al (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594 430 PMID: 34079124
If you know of a relevant reference for LP 922056, please let us know.
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Keywords: LP 922056, LP 922056 supplier, LP922056, notum, inhibitors, inhibits, wnt, signaling, activators, activates, O-palmitoleoyl-L-serine, hydrolase, pectinacetylesterase, osteoprorosis, NOTUMi, Other, Wnt, Signaling, Hydrolases, 6691, Tocris Bioscience
Citations for LP 922056
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