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Submit ReviewLUF 5834
Description: Potent adenosine A2A and A2B receptor partial agonist
Chemical Name: 2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
Purity: ≥98% (HPLC)
Biological Activity for LUF 5834
LUF 5834 is a potent A2A and A2B adenosine receptor partial agonist (Ki = 2.6 nM and EC50 = 12 nM respectively). Also exhibits selectivity for A1 over A3 (Ki values are 2.6 and 538 nM respectively).
Compound Libraries for LUF 5834
LUF 5834 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LUF 5834
| M. Wt | 348.38 |
| Formula | C17H12N6OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 333962-91-7 |
| PubChem ID | 1150683 |
| InChI Key | WLBUICQBNZXIDJ-UHFFFAOYSA-N |
| Smiles | NC1=NC(SCC3=NC=CN3)=C(C#N)C(C2=CC=C(O)C=C2)=C1C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LUF 5834
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.84 | 100 |
Preparing Stock Solutions for LUF 5834
The following data is based on the product molecular weight 348.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets for LUF 5834
References for LUF 5834
References are publications that support the biological activity of the product.
Beukers et al (2004) New, non-adenosine, high potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 47 3707 PMID: 15239649
Lane et al (2012) A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2a receptor Mol.Pharmacol. 81 475 PMID: 22188926
If you know of a relevant reference for LUF 5834, please let us know.
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Keywords: LUF 5834, LUF 5834 supplier, LUF5834, potent, A2A, A2B, adenosine, receptors, agonists, Adenosine, Receptors, 4603, Tocris Bioscience
2 Citations for LUF 5834
Citations are publications that use Tocris products. Selected citations for LUF 5834 include:
Kurt et al (2021) A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch. Structure 29 170-176.e3 PMID: 33238145
Gemma et al (2020) Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. Comput Struct Biotechnol J 18 2723-2732 PMID: 33101610
Do you know of a great paper that uses LUF 5834 from Tocris? Please let us know.
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