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Submit ReviewLY 2119620
Description: Positive allosteric modulator of M2 and M4 receptors
Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for LY 2119620
LY 2119620 is a positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.
Technical Data for LY 2119620
| M. Wt | 437.94 |
| Formula | C19H24ClN5O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 886047-22-9 |
| PubChem ID | 57664406 |
| InChI Key | TYTGOXSAAQWLPJ-UHFFFAOYSA-N |
| Smiles | CN1CCN(CC1)C(=O)COC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC1CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 2119620
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.79 | 100 | |
| 1eq. HCl | 43.79 | 100 |
Preparing Stock Solutions for LY 2119620
The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.42 mL | 22.83 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.57 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for LY 2119620
References for LY 2119620
References are publications that support the biological activity of the product.
Croy et al (2014) Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol.Pharmacol. 86 106 PMID: 24807965
Kruse et al (2013) Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504 101 PMID: 24256733
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Keywords: LY 2119620, LY 2119620 supplier, LY2119620, muscarinic, acetylcholine, ach, receptor, M2, M4, positive, allosteric, modulators, PAM, potentiates, modulates, mAChRs, Receptors, 6964, Tocris Bioscience
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