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Submit ReviewLY 235959
Description: Competitive NMDA antagonist
Chemical Name: [3S-(3α,4aα,6β,8aα)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid)
Biological Activity for LY 235959
LY 235959 is a competitive NMDA receptor antagonist.
Licensing Information
Sold with the permission of Eli Lilly and Company.
Technical Data for LY 235959
| M. Wt | 277.26 |
| Formula | C11H20NO5P |
| Storage | Desiccate at +4°C |
| CAS Number | 137433-06-8 |
| PubChem ID | 131938 |
| InChI Key | STIRHCNEGQQBOY-QEYWKRMJSA-N |
| Smiles | [H][C@]12[C@](CC[C@H](CP(O)(O)=O)C2)([H])CN[C@H]([C@](O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LY 235959
References for LY 235959
References are publications that support the biological activity of the product.
Borowicz et al (1996) Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia 37 618 PMID: 8681893
Ellison (1994) Competitive and non-competitive NMDA antagonists induce similar limbic degeneration. Neuroreport 5 2688 PMID: 7696633
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Keywords: LY 235959, LY 235959 supplier, Competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, LY235959, 1019, Tocris Bioscience
2 Citations for LY 235959
Citations are publications that use Tocris products. Selected citations for LY 235959 include:
Kenny et al (2009) NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology 34 266 PMID: 18418357
Fowler et al (2011) Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature 471 597 PMID: 21278726
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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