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Description: Selective CCK2 antagonist
Chemical Name: (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for LY 288513
LY 288513 is a selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.
Licensing Information
Sold with the permission of Eli Lilly and Company
Technical Data for LY 288513
| M. Wt | 436.3 |
| Formula | C22H18BrN3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 147523-65-7 |
| PubChem ID | 2802894 |
| InChI Key | LMUQHXHWJWQXSD-PMACEKPBSA-N |
| Smiles | BrC1=CC=C(NC(=O)N2NC(=O)[C@H]([C@@H]2C2=CC=CC=C2)C2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 288513
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.63 | 100 |
Preparing Stock Solutions for LY 288513
The following data is based on the product molecular weight 436.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.46 mL | 22.92 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for LY 288513
References for LY 288513
References are publications that support the biological activity of the product.
Rasmussen (1994) CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain DA neurons. Ann.N.Y.Acad.Sci. 713 300 PMID: 8185172
Helton et al (1996) Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol.Biochem.Behav. 53 493 PMID: 8866946
Rasmussen et al (1992) Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain DA neurons. J.Pharmacol.Exp.Ther. 264 480
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Keywords: LY 288513, LY 288513 supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, LY288513, Receptor, 1524, Tocris Bioscience
1 Citation for LY 288513
Citations are publications that use Tocris products. Selected citations for LY 288513 include:
Wen et al (2012) Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular mor. dependence. Front Endocrinol (Lausanne) 13 63 PMID: 22682150
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