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Submit ReviewLY 379268 disodium salt
Description: Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)
Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt
Purity: ≥98% (HPLC)
Biological Activity for LY 379268 disodium salt
LY 379268 disodium salt is a sodium salt of LY 379268 (Cat. No. 2453), a highly selective group II mGlu receptor agonist.
Technical Data for LY 379268 disodium salt
| M. Wt | 231.11 |
| Formula | C7H7NNa2O5 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 10197984 |
| InChI Key | YASVRZWVUGJELU-MDASVERJSA-N |
| Smiles | [H][C@]12[C@]([C@H]2[C@](O[Na])=O)([H])[C@@]([C@](O[Na])=O)(N)CO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 379268 disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.11 | 100 |
Preparing Stock Solutions for LY 379268 disodium salt
The following data is based on the product molecular weight 231.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.33 mL | 21.63 mL | 43.27 mL |
| 5 mM | 0.87 mL | 4.33 mL | 8.65 mL |
| 10 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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Product Datasheets for LY 379268 disodium salt
References for LY 379268 disodium salt
References are publications that support the biological activity of the product.
Bond et al (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 273 PMID: 10515191
Bond et al (2000) Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 294 800 PMID: 10945827
Collado et al (2002) (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 45 3619 PMID: 12166935
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Keywords: LY 379268 disodium salt, LY 379268 disodium salt supplier, LY379268, disodium, salt, 2Na, selective, group, II, agonists, Group, Receptors, mGlu2, mGluR2, mGlu3, mGluR3, Glutamate, Metabotropic, (Metabotropic), 5064, Tocris Bioscience
2 Citations for LY 379268 disodium salt
Citations are publications that use Tocris products. Selected citations for LY 379268 disodium salt include:
Craig W et al (2021) Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus. Biol Psychiatry 90 385-398 PMID: 33965197
Javier et al (2020) Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells. Cell Chem Biol 27 1308-1317.e4 PMID: 32726588
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
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