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Submit ReviewLys-γ3-MSH
Description: Pro-opiomelanocortin (POMC) derived peptide
Biological Activity for Lys-γ3-MSH
Lys-γ3-MSH is a pro-opiomelanocortin (POMC) derived peptide. Potentiates the steriodogenic action of corticotrophin on the adrenal cortex, possibly via the MC3 receptor. Potently stimulates lipolysis via activation of hormone-sensitive lipase (HSL).
Technical Data for Lys-γ3-MSH
| M. Wt | 3018.27 |
| Formula | C128H193N45O39S |
| Sequence | KYVMGHFRWDRFGRRNSSSSGSSGAGQ |
| Storage | Store at -20°C |
| CAS Number | 156159-18-1 |
| PubChem ID | 90488867 |
| InChI Key | XWFHPHMLENMPDT-KLQUGMGCSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Lys-γ3-MSH
References for Lys-γ3-MSH
References are publications that support the biological activity of the product.
Harmer et al (2008) Evidence of a possible role fo Lys-γ3-MSH in the regulation of adipocyte function. J.Endocrinol. 196 149 PMID: 18180326
Bicknell et al (2009) Lys-gamma3-MSH: a global regulator of hormone-sensitive lipase activity? Mol.Cell.Endocrinol. 300 71 PMID: 18977407
Harmer and Bicknell (2004) The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal. Endocrine Res. 30 629
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Keywords: Lys-gamma3-MSH, Lys-gamma3-MSH supplier, Pro-opiomelanocortin, POMC, hormone-sensitive, lipase, activators, HSL, melanocortin, receptors, Hydrolases, Lys-γ3-MSH, Lys-gamma3-MSH, Lys-γ3-Melanocyte-stimulating, Lys-gamma3-Melanocyte-stimulating, hormone, Melanocortin, Receptors, Other, 3611, Tocris Bioscience
Citations for Lys-γ3-MSH
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Currently there are no citations for Lys-γ3-MSH.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.