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Submit ReviewM 084 hydrochloride
Description: TRPC4 and TRPC5 inhibitor; antidepressant and anxiolytic
Chemical Name: N-Butyl-1H-benzimidazol-2-amine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for M 084 hydrochloride
M 084 hydrochloride is a TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.
Technical Data for M 084 hydrochloride
| M. Wt | 225.72 |
| Formula | C11H15N3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1992047-63-8 |
| PubChem ID | 121513894 |
| InChI Key | DMLSYUAQEOLJQC-UHFFFAOYSA-N |
| Smiles | CCCCNC1=NC2=CC=CC=C2N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for M 084 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.57 | 100 | |
| DMSO | 22.57 | 100 |
Preparing Stock Solutions for M 084 hydrochloride
The following data is based on the product molecular weight 225.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.43 mL | 22.15 mL | 44.3 mL |
| 5 mM | 0.89 mL | 4.43 mL | 8.86 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.43 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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Product Datasheets for M 084 hydrochloride
References for M 084 hydrochloride
References are publications that support the biological activity of the product.
Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID: 25816897
Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID: 26317356
If you know of a relevant reference for M 084 hydrochloride, please let us know.
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Keywords: M 084 hydrochloride, M 084 hydrochloride supplier, M084, hydrochloride, TRPC4/5, blockers, inhibitors, inhibits, transient, receptor, potential, channels, canonical, TRPC, 5807, Tocris Bioscience
2 Citations for M 084 hydrochloride
Citations are publications that use Tocris products. Selected citations for M 084 hydrochloride include:
Melitta et al (2022) Interactions between the Polysialylated Neural Cell Adhesion Molecule and the Transient Receptor Potential Canonical Channels 1, 4, and 5 Induce Entry of Ca2+ into Neurons. Int J Mol Sci 23 PMID: 36077460
Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946
Do you know of a great paper that uses M 084 hydrochloride from Tocris? Please let us know.
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