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Description: Histone deacetylase inhibitor
Chemical Name: 4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for M 344
M 344 is a histone deacetylase inhibitor (IC50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
Technical Data for M 344
| M. Wt | 307.39 |
| Formula | C16H25N3O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 251456-60-7 |
| PubChem ID | 3994 |
| InChI Key | MXWDSZWTBOCWBK-UHFFFAOYSA-N |
| Smiles | O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for M 344
References for M 344
References are publications that support the biological activity of the product.
Jung et al (1999) Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J.Med.Chem. 42 4669 PMID: 10579829
Takai et al (2006) M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol.Oncol. 101 108 PMID: 16263156
Riessland et al (2006) The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum.Genet. 120 101 PMID: 16724231
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Keywords: M 344, M 344 supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, M344, epigenetics, Non-selective, HDACs, Non-Selective, 2771, Tocris Bioscience
Citations for M 344
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Currently there are no citations for M 344.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.