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Description: Dynamin-related GTPase DRP1 partial inhibitor
Chemical Name: 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for MB 0223
MB 0223 is a dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion.
Technical Data for MB 0223
| M. Wt | 457.59 |
| Formula | C26H27N5OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2247732-89-2 |
| PubChem ID | 135368613 |
| InChI Key | SWLKFZCOJAYAMJ-UHFFFAOYSA-N |
| Smiles | CC1=CN(C(C(NC2=CC=C(C3=CN=CC=C3)C=C2)=O)=C1)CC4=CSC(N5CCCCC5)=N4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MB 0223
References for MB 0223
References are publications that support the biological activity of the product.
Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID: 29601815
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Keywords: MB 0223, MB 0223 supplier, MB0223, DRP1, dynamin, related, GTPase, inhibitors, inhibits, partial, mitochondrial, dynamics, division, Dynamin, 6799, Tocris Bioscience
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