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Discontinued Product
0712 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Group II mGlu agonist/antagonist
Chemical Name: (2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine
Biological Activity for MCCG
Group II metabotropic glutamate receptor antagonist in electrophysiological studies and at cloned receptors. Group II mGlu agonist in adult rat cerebrocortical slices.
Technical Data for MCCG
| M. Wt | 173.17 |
| Storage | Store at RT |
| CAS Number | 157381-42-5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MCCG
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Please contact Customer Service
References for MCCG
References are publications that support the biological activity of the product.
Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809 PMID: 7921606
Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79 PMID: 8864697
Knöpfel et al (1995) Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes. Neuropharmacology 34 1099 PMID: 8532159
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
View Related Products by Target
View Related Products by Product Action
View all Glutamate (Metabotropic) Group II Receptor Agonists
Keywords: MCCG, MCCG supplier, Glutamate, (Metabotropic), Group, II, Receptors, 0712, Tocris Bioscience
Citations for MCCG
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.