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Submit ReviewMDL 73005EF hydrochloride
Description: Potent and selective 5-HT1A partial agonist
Chemical Name: 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for MDL 73005EF hydrochloride
MDL 73005EF hydrochloride is a potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.
Technical Data for MDL 73005EF hydrochloride
| M. Wt | 394.9 |
| Formula | C20H26N2O4.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 102908-60-1 |
| PubChem ID | 56972149 |
| InChI Key | UEDYXFOPCMTXEH-UHFFFAOYSA-N |
| Smiles | Cl.O=C1CC2(CCCC2)CC(=O)N1CCNCC1COC2=C(O1)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDL 73005EF hydrochloride
References for MDL 73005EF hydrochloride
References are publications that support the biological activity of the product.
Buisson Defferier and Van den Buuse (1992) Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats. Eur.J.Pharmacol. 223 133 PMID: 1362161
Gartside et al (1990) Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A receptor function in the rat in vivo. Eur.J.Pharmacol. 191 391 PMID: 1964908
Van der Hooff and Galvan (1991) Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. Eur.J.Pharmacol. 196 291 PMID: 1893914
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Citations for MDL 73005EF hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.