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Submit ReviewMephenytoin
Description: CYP2C19 substrate. Anticonvulsant
Chemical Name: (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
Purity: ≥98% (HPLC)
Biological Activity for Mephenytoin
Mephenytoin is a CYP2C19 and CYP2B6 substrate. Anticonvulsant.
Technical Data for Mephenytoin
| M. Wt | 218.25 |
| Formula | C12H14N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 50-12-4 |
| PubChem ID | 4060 |
| InChI Key | GMHKMTDVRCWUDX-UHFFFAOYSA-N |
| Smiles | O=C1C(C2=CC=CC=C2)(CC)NC(N1C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Mephenytoin
References for Mephenytoin
References are publications that support the biological activity of the product.
Knabe and Wunn (1980) Racemic and optically active hydantoins from disubstituted cyanoacetic acids. Arch.Pharmacol. 313 53
Foti et al (2008) CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles. Drug Meta. Dispos. 36 523 PMID: 18048485
Tamminga et al (2001) Mephenytoin as a probe for CYP2C19 phenotyping: effect of sample storage, intra-individual reproducibility and occurrence of adverse events. Br.J.Clin.Pharmacol. 51 471 PMID: 11422005
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Keywords: Mephenytoin, Mephenytoin supplier, CYP2C19, Anticonvulsant, Cytochrome, P450, 3276, Tocris Bioscience
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