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Submit ReviewMethylmalonate
Description: Succinate dehydrogenase inhibitor
Chemical Name: 2-Methylpropanedioic acid
Purity: ≥98%
Biological Activity for Methylmalonate
Methylmalonate is an intracellularly produced malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
Technical Data for Methylmalonate
| M. Wt | 118.09 |
| Formula | C4H6O4 |
| Storage | Store at RT |
| Purity | ≥98% |
| CAS Number | 516-05-2 |
| PubChem ID | 487 |
| InChI Key | ZIYVHBGGAOATLY-UHFFFAOYSA-N |
| Smiles | OC(C(C)C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Methylmalonate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 11.81 | 100 | |
| DMSO | 11.81 | 100 |
Preparing Stock Solutions for Methylmalonate
The following data is based on the product molecular weight 118.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.47 mL | 42.34 mL | 84.68 mL |
| 5 mM | 1.69 mL | 8.47 mL | 16.94 mL |
| 10 mM | 0.85 mL | 4.23 mL | 8.47 mL |
| 50 mM | 0.17 mL | 0.85 mL | 1.69 mL |
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Product Datasheets for Methylmalonate
References for Methylmalonate
References are publications that support the biological activity of the product.
Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373 PMID: 15100720
McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279 PMID: 9692761
Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270 PMID: 22441874
If you know of a relevant reference for Methylmalonate, please let us know.
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Keywords: Methylmalonate, Methylmalonate supplier, methylmalonate, succinate, dehydrogenase, inhibitors, inhibits, malonate, Huntingtons, disease, HD, mitochondrial, toxins, Other, Dehydrogenases, Oxidative, Phosphorylation, 4979, Tocris Bioscience
1 Citation for Methylmalonate
Citations are publications that use Tocris products. Selected citations for Methylmalonate include:
Belinskaia et al (2019) Psychotropic Drugs for the Management of Chronic Pain and Itch. Pharmaceuticals (Basel) 12 PMID: 31238561
Do you know of a great paper that uses Methylmalonate from Tocris? Please let us know.
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