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Submit ReviewMethysergide maleate
Description: 5-HT1/5-HT2 antagonist
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide maleate
Purity: ≥99% (HPLC)
Biological Activity for Methysergide maleate
Methysergide maleate is a mixed 5-HT1/5-HT2 receptor antagonist.
Technical Data for Methysergide maleate
| M. Wt | 469.54 |
| Formula | C21H27N3O2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 129-49-7 |
| PubChem ID | 5281073 |
| InChI Key | LWYXFDXUMVEZKS-ZVFOLQIPSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Methysergide maleate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.7 | 10 with gentle warming |
Preparing Stock Solutions for Methysergide maleate
The following data is based on the product molecular weight 469.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.3 mL | 106.49 mL | 212.97 mL |
| 0.5 mM | 4.26 mL | 21.3 mL | 42.59 mL |
| 1 mM | 2.13 mL | 10.65 mL | 21.3 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
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Product Datasheets for Methysergide maleate
References for Methysergide maleate
References are publications that support the biological activity of the product.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Merck Index 12 6217
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Keywords: Methysergide maleate, Methysergide maleate supplier, 5-HT1, 5-HT2, antagonists, Non-Selective, 5-Hydroxytryptamine, Receptors, Serotonin, Non-selective, 5-HT, 1064, Tocris Bioscience
7 Citations for Methysergide maleate
Citations are publications that use Tocris products. Selected citations for Methysergide maleate include:
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Dacks et al (2009) Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurosci 23 366 PMID: 19863268
Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. Neuron 29 13909 PMID: 19890001
Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126
Williams et al (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz. Neuropsychopharmacology 37 2285 PMID: 22692564
Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. Hypertension 31 1863 PMID: 21289196
González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. J Neurosci 53 439 PMID: 17270739
Do you know of a great paper that uses Methysergide maleate from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.