Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMetoprolol tartrate
Description: Selective β1 antagonist
Chemical Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate
Purity: ≥99% (HPLC)
Biological Activity for Metoprolol tartrate
Metoprolol tartrate is a selective β1-adrenoceptor antagonist (Ki values are 47, 2960 and 10100 nM for β1, β2 and β3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.
Compound Libraries for Metoprolol tartrate
Metoprolol tartrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Metoprolol tartrate
| M. Wt | 342.4 |
| Formula | C15H25NO3.½C4H6O6 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 56392-17-7 |
| PubChem ID | 6420057 |
| InChI Key | YGULWPYYGQCFMP-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)C(O)C(O)=O.OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.OC(CNC(C)C)COC2=CC=C(CCOC)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Metoprolol tartrate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.24 | 100 | |
| DMSO | 34.24 | 100 |
Preparing Stock Solutions for Metoprolol tartrate
The following data is based on the product molecular weight 342.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Metoprolol tartrate
References for Metoprolol tartrate
References are publications that support the biological activity of the product.
Garlichs et al (1999) Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells. Eur.J.Clin.Invest. 29 12 PMID: 10092983
Dasbiswas et al (2008) S-metoprolol: The 2008 Clinical Review. J.Indian.Med.Assoc. 106 259 PMID: 18828349
Hoffmann et al (2004) Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmied.Arch.Pharmacol. 369 151 PMID: 14730417
If you know of a relevant reference for Metoprolol tartrate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Metoprolol tartrate, Metoprolol tartrate supplier, Selective, α1-adrenoceptor, beta1-adrenoceptor, b1-adrenoceptor, antagonists, b1-adrenergic, β1-Adrenergic, beta1-Adrenergic, Receptors, Adrenergic, Beta-1, 3256, Tocris Bioscience
Citations for Metoprolol tartrate
Citations are publications that use Tocris products.
Currently there are no citations for Metoprolol tartrate. Do you know of a great paper that uses Metoprolol tartrate from Tocris? Please let us know.
Reviews for Metoprolol tartrate
There are currently no reviews for this product. Be the first to review Metoprolol tartrate and earn rewards!
Have you used Metoprolol tartrate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.