Mevastatin

Discontinued Product

1526 has been discontinued.

View all HMG-CoA Reductase products.
Description: HMG-CoA reductase inhibitor
Alternative Names: Compactin
Chemical Name: (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (2)

Biological Activity for Mevastatin

Mevastatin is an inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data for Mevastatin

M. Wt 390.52
Formula C23H34O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 73573-88-3
PubChem ID 64715
InChI Key AJLFOPYRIVGYMJ-INTXDZFKSA-N
Smiles [H][C@@]12C(C=C[C@H](C)[C@@]([H])2CC[C@@]3([H])OC(C[C@]([H])(O)C3)=O)=CCC[C@@H]1OC([C@@H](C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: Mevastatin, Mevastatin supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Compactin, Reductase, 1526, Tocris Bioscience

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.